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Areas of specialization
Exercise physiology, obesity, metabolism, vascular biology
Research interests
The focus of my research since 1991 has revolved
around the metabolic syndrome and lifestyle modification as a
treatment of this metabolic condition. My initial studies
examined the effects of weight loss and physical activity on
carbohydrate metabolism and older, obese hypertensive
individuals. Recently, my research has focused on the metabolic
syndrome in overweight children and adolescents. Although the
metabolic syndrome is thought to be due to the development of
obesity that occurs during aging, we have discovered an
increasing number of obese children that are displaying similar
characteristics of this disease. I am currently are conducting a
series of studies that are examining blood vessel structure and
function and the metabolic syndrome in overweight and obese
children before and after lifestyle modifications such as:
aerobic exercise training, weight loss and resistance training.
[Read more at "Saving
Young Hearts".]
In addition to our recent studies in overweight
and obese children, I have begun to examine blood vessel
structure and function and the metabolic syndrome in adult
survivors of childhood acute lymphoblastic leukemia. Although
these individuals are cancer free they develop a number of
metabolic conditions associated with the metabolic syndrome.
These studies will be expanded to examine child (ages 8-18 yrs)
survivors of various forms of cancer and the effect of their
cancer treatments on blood vessel structure and function.
Education
- 1990-1994, National Institute of Aging Postdoctoral
Research Fellow, Division of Gerontology, University of
Maryland School of Medicine, Baltimore, Maryland
(Laboratories of Drs. Andrew P. Goldberg and James M.
Hagberg); post-doctoral training
- 1987-1990, University of Georgia, Athens, Georgia; Ph.D.
(exercise/applied physiology)
- 1984-1986, Ball State University, Muncie, Indiana; M.A.
(exercise/applied physiology)
- 1979-1984, University of Wisconsin, LaCrosse, Wisconsin;
B.S. (magna cum laude, honors in physical education)
- 1979-1984, University of Wisconsin, LaCrosse, Wisconsin;
B.S. (magna cum laude, honors in health education)
Selected works
Dengel DR, Pratley RE, Hagberg JM, Rogus EM,
Goldberg AP: Distinct effects of aerobic exercise training and
weight loss on glucose homeostasis in obese sedentary men.
Journal of Applied Physiology 81:318-325, 1996.
Dengel DR, Brown MD, Ferrell RE, Reynolds
TH, Supiano MA: Exercise-induced enhancements in insulin action
are associated with ACE gene polymorphisms in older
hypertensives.
Physiological Genomics 11:73-80, 2002.
Alexander NB, Dengel DR, Olson RJ, Krajewski
KM: Oxygen uptake (VO2) kinetics and functional mobility
performance in impaired older adults. Journal of Gerontology:
Biological Sciences 58A(8):734-739, 2003.
Kelly AS, Wetzsteon RJ, Kaiser DR,
Steinberger J, Bank AJ, Dengel DR: Inflammation, insulin, and
endothelial function in overweight children and adolescents: the
role of exercise.
Journal of Pediatrics 145(6):731-736, 2004.
Lee C, Glickman SG, Dengel DR, Brown MD,
Supiano MA: Abdominal adiposity assessed by dual energy X-ray
absorptiometry provides a sex-independent predictor of insulin
sensitivity in older adults. Journal of Gerontology: Medical
Sciences 60A:872-877, 2005.
Academic appointments
- 2003-present, co-director, Body Composition Human
Performance, General Clinical Research Center, University of
Minnesota
- 2003-present, associate professor, School of Kinesiology, University of Minnesota
- 2000-2003, assistant professor, School of Kinesiology,
University of Minnesota
- 2000-present, research scientist, Research Service,
Minneapolis VAMC
- 1996-2000, faculty associate, Institute of Gerontology,
University of Michigan
- 1995-2000, assistant research scientist, Department of
Internal Medicine, University of Michigan
- 1995-2000, adjunct assistant professor, Division of
Kinesiology, University of Michigan
- 1995-2000, research scientist, Geriatric Research
Education and Clinical Center, Ann Arbor VA Medical Center
- 1994-1995, research associate, Division of Gerontology,
University of Maryland School of Medicine
Honors and awards
- 1997, New Investigator Award, American College of Sports
Medicine
- 1994, Fellow, American College of Sports Medicine
- 1991, National Research Service Award from NIH (NRSA)
- 1984, Magna Cum Laude, University of Wisconsin-La Crosse
- 1983, Sigma Zeta National Science Honor Society
Research activities
Bibliography
Peer-reviewed publications
Kelly AS, Kaiser DR, Dengel DR, Bank AJ:
Comparison of B-mode and echo-tracking methods of assessing
flow-mediated dilation.
Ultrasound in Medicine and Biology 30(11):1447-1449,
2004.
Kelly AS, Wetzsteon RJ, Kaiser DR,
Steinberger J, Bank AJ, Dengel DR: Inflammation, insulin, and
endothelial function in overweight children and adolescents: the
role of exercise.
Journal of Pediatrics 145(6):731-736, 2004.
Glickman SG, Marn CS, Mark A. Supiano MA,
Dengel DR: Validity and reliability of dual-energy X-ray
absorptiometry for the assessment of abdominal adiposity.
Journal of Applied Physiology 97:509-514, 2004.
Reynolds TH, Supiano MA, Dengel DR:
Resistance training enhances insulin-mediated glucose disposal
with minimal effect on the tumor necrosis factor-alpha system in
older hypertensives.
Metabolism 53(3):397-402, 2004.
Reynolds TH, Pamela Reid P, Larkin LM,
Dengel DR: Effects of aerobic exercise training on the protein
kinase B (PKB)/mammalian target of rapamycin (mTOR) signaling
pathway in aged skeletal muscle. Experimental Gerontology
39: 379-385, 2004.
Alexander NB, Dengel DR, Olson RJ, Krajewski
KM: Oxygen uptake (VO2) kinetics and functional mobility
performance in impaired older adults. Journal of Gerontology:
Biological Sciences 58A(8):734-739, 2003.
Dengel DR, Brown MD, Ferrell RE, Reynolds
TH, Supiano MA: Exercise-induced enhancements in insulin action
are associated with ACE gene polymorphisms in older
hypertensives.
Physiological Genomics 11:73-80, 2002.
Reynolds TH, Krajewski KM, Larkin LM, Reid
P, Halter JB, Supiano MA, Dengel DR: Effect of age on skeletal
muscle proteolysis in extensor digitorum longus muscles of
B6C3F1 mice.
Journal of Gerontology: Biological Sciences
57A:B198-B201, 2002.
Brown MD, Dengel DR, Hogikyan RV, Supiano
MA: Sympathetic activity and the heterogeneous blood pressure
response to exercise training in hypertensives. Journal of
Applied Physiology
92:1434-1442, 2002
Dengel DR, Brown MD, Ferrell RE, Supiano MA:
Role of angiotensin converting enzyme genotype in sodium
sensitivity in older hypertensives. American Journal of
Hypertension
14:1178-1184, 2001.
Pratley RE, Hagberg JM, Dengel DR, Muller
DC, Rogus EM, Goldberg AP: Aerobic exercise training-induced
reductions in abdominal fat and glucose stimulated insulin
responses in middle-aged and older men. Journal of American
Geriatrics Society 9:1055-1061, 2000.
Brown MD, Hogikyan RV, Dengel DR, Supiano
MA: Sodium-sensitive hypertension is not associated with
higher sympathetic nervous system activity in older hypertensive
humans.
American Journal of Hypertension. 13:873-883, 2000.
Feely RS, Larkin LM, Halter JB, Dengel DR:
Chemical vs. dual energy X-ray absorptiometry for detecting
age-associated body compositional changes in male rats.
Experimental Gerontology
13:417-427, 2000.
Taylor-Tolbert NS, Dengel DR, Brown MD,
McCole SD, Pratley RE, Ferrell RE, Hagberg JM: Ambulatory blood
pressure after acute exercise in older men with essential
hypertension.
American Journal of Hypertension 13(1):44-51, 2000.
Brown MD, Srininvasan M, Hogikyan RV, Dengel
DR, Glickman SG, Galecki A, Supiano MA: Nitric oxide biomarkers
increase during exercise-induced vasodilatation in the forearm.
International Journal of Sports Medicine 21:83-89, 2000.
Hagberg JM, Ferrell RE, Dengel DR, Wilund
KR: Exercise training-induced blood pressure and plasma lipid
improvements may be genotype dependent. Hypertension
34:18-23, 1999.
Hagberg JM, Ferrell RE, Katzel LI, Dengel
DR, Sorkin JD, Goldberg AP: Apolipoprotein E , genotype and
exercise training-induced increases in plasma high-density
lipoprotein (HDL)- and HDL2-cholesterol levels in overweight
men. Metabolism
48(8):943-945, 1999.
Dengel DR, Hogikyan RV, Brown MD, Glickman
SG, Supiano MA: Insulin sensitivity is , associated with blood
pressure response to sodium in older hypertensives. American
Journal of Physiology 274(37):E403-E409, 1998.
Dengel DR, Hagberg JM, Pratley RE, Rogus EM,
Goldberg AP: Improvements in blood pressure, glucose metabolism,
and lipoprotein lipids after aerobic exercise plus weight loss
inobese, hypertensive middle-aged men. Metabolism
47:1075-1082, 1998.
Dengel DR, Galecki AT, Hagberg JM, Pratley
RE: The independent and combined effects ofweight loss and
aerobic exercise on blood pressure and oral glucose tolerance in
older men. American Journal of Hypertension 11:1405-1412,
1998.
Macko RF, DeSouza CA, Tretter LD, Silver KH,
Smith GV, Anderson PA, Tomoyaus N, Gorman P, Dengel DR:
Treadmill aerobic exercise training reduces the energy
expenditure and cardiovascular demands of hemiparetic gait in
chronic stroke patients. Stroke
28:326-330, 1997.
Macko RF, Katzel LI, Yataco A, Tretter LD,
DeSouza CA, Dengel DR, Smith GV, Silver KH. Low velocity graded
treadmill stress testing in hemiparetic stroke patients.
Stroke 28:988-993, 1997.
DeSouza CA, Dengel DR, Rogers MA, Cox K,
Macko RF: Fibrinolytic responses to acute physical activity in
older hypertensive men. Journal of Applied Physiology
82(6): 1765-1770, 1997.
Dengel DR, Mayuga RS, Kairis GM, Goldberg
AP, and Weir MR. Effect of dietary sodium on insulin sensitivity
in middle-aged, obese, sedentary hypertensives. American
Journal of Hypertension 10 (Part I):964-970, 1997.
DeSouza CA, Dengel DR, Macko RF, Cox K,
Seals DR: Elevated levels of circulation cell adhesion molecules
in uncomplicated essential hypertension. American Journal of
Hypertension
10:1335-1341, 1997.
DeSouza CA, Dengel DR, Rogers MA, Cox K,
Macko RF: The fibrinolytic system is not impaired in older men
with hypertension.
Hypertension 27:1053-1058, 1996.
Dengel DR, Goldberg AP, Mayuga RS, Kairis
GM, Weir MR: Insulin resistance, elevated glomerular filtration
fraction and renal injury. Hypertension 28:127-132, 1996.
Dengel DR, Pratley RE, Hagberg JM, Rogus EM,
Goldberg AP: Distinct effects of aerobic exercise training and
weight loss on glucose homeostasis in obese sedentary men.
Journal of Applied Physiology 81:318-325, 1996.
Weir MR, Dengel DR, Behrens MT, Goldberg AP:
Salt-induced increases in systolic blood pressure affect renal
hemodynamics and proteinuria. Hypertension 25:1339-1344,
1995.
Dengel DR, Pratley RE, Hagberg JM, Goldberg
AP: Impaired insulin sensitivity and maximal responsiveness in
older hypertensives. Hypertension 23:320-324, 1994.
Dengel DR, Hagberg JM, Coon PJ, Drinkwater
DT, Goldberg AP: Effects of weight loss by diet alone or
combined with aerobic exercise on body composition in older
obese men. Metabolism
43:867-871, 1994.
Dengel DR, Hagberg JM, Coon PJ, Drinkwater
DT, Goldberg AP: Effects of hypocaloric diet therapy with and
without aerobic exercise on body fat distribution patterns in
older obese men. Medicine and Science in Sports and Exercise
26:1307-1315, 1994.
Dengel DR, Weyand PG, Black DM, Cureton KJ:
Effects of hypohydration on ratings of perceived exertion at the
lactate and ventilatory thresholds. International Journal of
Sports Nutrition 3:376-386, 1993.
Lewis RD, Johnson MA, Dengel DR, Jones MT,
Norton KI: The effects of maternal training on plasma copper,
magnesium and zinc rats. Nutrition Research 13:771-778,
1993.
Dengel DR, Weyand PG, Black DM, Cureton KJ:
Effect of varying levels of hypohydration on responses during
submaximal cycling. Medicine and Science in Sports and
Exercise 24:1096-1101, 1992.
Conley DS, Cureton KJ, Dengel DR, Weyand PG:
Validation of the 12-min swim as a field test of peak aerobic
power in young men. Medicine and Science in Sports and
Exercise
23:766-773, 1991.
Chapters in books
Dengel DR, Reynolds TH: Diabetes. In: LeMura
LM and von Duvillard SP (eds), Clinical Exercise Physiology:
Application and Physiological Principles. Baltimore, MD:
Lippincott, Williams and Wilkins, pp. 319-329, 2004.
Goldberg AP, Hagberg JM, Dengel DR: Exercise
physiology and aging. In: Schneider EL and, Rowe JW (eds.),
Handbook
of The Biology of Aging. 4th edition. New York: Academic
Press, Inc. pp. 331-354, 1996.
Dengel DR, Kearney JT, Fleck SJ: Performer
readiness for amateur boxing. In: King LA (ed.), Safety
Awareness Manual of the USA Amateur Boxing Federation.
Colorado Springs, CO: USA Amateur Boxing Federation, pp. 31-43,
1989.
Monographs
Dibner RD, Shubin MM, Taylor-Tolbert N,
Dengel DR, McCole SD, Brown MD, Hagberg JM: Effect of exercise
training and acute exercise on essential hypertensives. In:
Rogozkin VA, Maughan R (eds.), Current Research in Sports
Science: An International Perspective. New York: Plenum Press,
pp. 295-301, 1996.
Van Handel PJ, Dengel DR, Kearney JT,
Bradley PW: A valid and reliable method for sampling blood
lactate under field or laboratory condi¬tions. In: Tenenbaum G,
Eiger D (eds.), Proceedings of The Maccabiah-Wingate
International Congress. Tel-Aviv, Israel: The Emmanuel Gill
Publishing House, pp. 38-47, 1990.
Articles in press
Lee CC, Glickman SG, Dengel DR, Brown MD,
Supiano MA: Abdominal adiposity assessed by dual energy x-ray
absorptiometry provides a gender-independent predictor of
insulin sensitivity in older adults. Journal of Gerontology:
Biological Sciences
(in press).
Articles in review
Dengel DR, Kelly AS, Olson TP, Kaiser DR,
Dengel JL, Bank AJ: Six Months of Weight Loss Improves Metabolic
and Vascular Indices in Overweight Adults. American Journal
of Hypertension
(in review).
Olson TP, Schmitz KH, Leon AS, Dengel DR:
Improved Vascular Function with Resistance Training in
Overweight and Obese Women. Circulation (in review).
Olson TP, Schlick LM, Dengel DR: Assessment
of Cerebral Blood Flow Velocity during Upright Maximal Cycle
Ergometry.
Medicine and Science in Sports and Exercise (in review).
Dengel DR, Kelly AS, Steinberger J, Sinaiko
AR: Effect of Oral Glucose Loading on Endothelial Function in
Normal and Overweight Children. Journal of Pediatrics (in
review).
Dengel DR, Goldberg AP, Hagberg JM, Muller
D, Pratley RE: Impaired glucose tolerance is associated with
obesity, physical deconditioning and lower insulin sensitivity
in middle-aged and older men. Journal of the American
Geriatric Society
(in review).
Dengel DR, Brown MD, Ferrell RE, Reynolds
TH, Supiano MA: Renal hemodynamic and blood pressure responses
to dietary sodium are associated with the t-786c endothelial
nitric oxide synthase gene. Physiological Genomics (in
review).
Olson TP, Tracy JE, Dengel DR: Validity of a
low-flow pneumotach and portable metabolic measurement system.
International Journal of Sports Medicine (in review).
Byard AD, Olson TP, Dengel DR: Validity of a
portable metabolic measurement system. European Journal of
Applied Physiology (in review).
Grant support
Current
National Multiple Sclerosis Society,
“Effects of a Home-based Aerobic Exercise Program for Persons
with Multiple Sclerosis”; Co-Investigator, 2005-2006
(approximately $44,000 direct costs)
Department of Veterans Affairs, “Aerobic
Performance, Mobility and Exercise in Older Adults With
Diabetes”; Co-Investigator, 2005-2009 (approximately $680,900
direct costs)
National Institute of Health, “Metabolic
Syndrome in Adult Survivors of Childhood ALL”; Co-Investigator,
2004-2006 (approximately $250,000 direct costs)
National Institute of Health, “Influence of
Insulin on BP Change During Adolescence”; Co-Investigators,
2004-2009 (approximately $2,500,000 direct costs)
Department of Veterans Affairs, “Functional
Circuit Training in Older Adults with Congestive Heart Failure”,
Co-Investigator, 2003-2007 (approximately $711,600 direct costs)
Minnesota Obesity Center, “The Effects of
Aerobic Exercise on Vascular Structure and Function in Obese
Children”; Co-Investigator, 2002-2005 (approximately $40,000
direct costs)
American Heart Association, “Dietary
Composition and Exercise Tolerance in Obese Adults”;
Co-Investigator, 2004-2008 (approximately $260,000 direct costs)
National Institute of Health, “Predicting
Energy Balance in Midlife Women”; Co-Investigator, 2005-2006
(approximately $281,846 direct costs)
Department of Veterans Affairs, “Aerobic
performance, mobility limitations and exercise in older adults
with diabetes”, Co-Investigator, 2005-2008 (approximately $701,
053 direct costs)
Recent
American Heart Association, “Effects of
Exercise Training on Vascular Endothelial Function and
Inflammation in Obese Children and Adolescents”; Sponsor,
2003-2005 (approximately $41,000 direct costs)
University of Minnesota, “Effects Of High
Carbohydrate Drinks On Vascular Function In Adolescents”;
Principal Investigator, 2002-2004 (approximately $24,191 direct
costs)
Department of Veterans Affairs, “Oxygen
Kinetics, Mobility Task Performance, and Task Training in Older
Adults”; Co-Investigator, 1999-2003 (approximately $540,400
direct costs)
Department of Veterans Affairs, “Insulin
Action: Role of Skeletal Muscle and Insulin-Mediated Blood
Flow”; Principal Investigator, 1998-2002 (approximately $493,600
direct costs)
University of Minnesota, “Measuring Human
Performance with the BioPAC System”; Co-Investigator, 2001-2002
(approximately $20,000 direct costs)
National Institute of Aging/National
Institute of Health (SERCA), “Insulin Action, Sodium and
Exercise in the Hypertension of Aging”; Principal Investigator,
1995-2000 (approximately $445,000 direct costs)
Pending
National Institute of Health, “Etiology of
Childhood Obesity (ECHO) Study”, Co-Investigator, 2004-2009
(approximately $3,470,500 direct costs)
National Institute of Health, “Obesity,
Exercise And Vascular Function In Children”; Principal
Investigator, 2004-2009 (approximately $1,856,250 direct costs)
National Institute of Health, “Metabolic
Syndrome Following Transplant for Leukemia”; Co-Investigator,
2004-2009 (approximately $1,314,179 direct costs)
National Institute of Health, “Physiology of
Human Adrenergic Gene Variants”; Co-Investigator, 2005-2010
(approximately $7,598,858 direct costs)
National Institute of Health, “Examining the
Obesity Epidemic through Youth, Family, and Young Adults”;
Co-Investigator, 2005-2010 (approximately $7,500,00 direct
costs)
National Institute of Health, “Metabolic
Syndrome in Childhood Cancer Survivors”, Co-Investigator,
2005–2009 (approximately $3,610,747 direct costs)
American Heart Association, “Effects of
antioxidant therapy on vascular endothelial function,
inflammation and adhesion in overweight children”, Principal
Investigator, 2005-2007 (approximately $132,000 direct costs)
Complete vitae
[.pdf]
Revised August 2005
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